Handbook on Cerebral Venous Thrombosis (Frontiers of by V. Caso, G Agnelli

By V. Caso, G Agnelli

Cerebral veins include approximately 70 consistent with cent of the whole cerebral blood quantity, yet cerebral venous thrombosis (CVT) happens a couple of thousand instances much less frequently than arterial stroke. CVT impacts typically teenagers and kids, and in approximately one area of instances the reason continues to be unknown. Written by means of overseas specialists, this e-book is facing epidemiology, hazard elements, coagulation issues, scientific presentation - in particular concentrating on headache, present neuroradiological remedy, issues and long term analysis of CVT. The e-book covers the total spectrum of CVT pathogenesis and provides a brand new and potent method of enhance previous analysis, realize new chance elements and to spot the main critical manifestations, which require extra competitive treatments.Neurologists, interventional neuroradiologists, neurosurgeons, and all physicians who're occupied with the care of sufferers with CVT will welcome this book as an invaluable and updated scientific advisor.

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Dentali F, Crowther M, Ageno W: Thrombophilic abnormalities, oral contraceptives, and risk of cerebral vein thrombosis: a meta-analysis. Blood 2006;107:2766–2773. Krayenbühl HA: Cerebral venous and sinus thrombosis. Clin Neurosurg 1966;14:1–24. Stam J: Thrombosis of the cerebral veins and sinuses. N Engl J Med 2005;352:1791–1798. de Bruijn SF, Stam J, Vandenbroucke JP: Increased risk of cerebral venous sinus thrombosis with third-generation oral contraceptives. Lancet 1998;351:1404. Jick SS, Jick H: Cerebral venous sinus thrombosis in users of four hormonal contraceptives: levonorgestrel-containing oral contraceptives, norgestimate-containing oral contraceptives, desogestrel-containing oral contraceptives and the contraceptive patch.

The great strength of these studies is that, since patients are randomly assigned to either treatment for the putative causal or some alternative treatment (another agent or no exposure at all), the study groups are similar not only in terms of already know determinants of outcome, but also in terms of currently unknown determinants [1]. g. smoking), it would not be ethical to randomly assign patients to exposure or nonexposure. In some situations, therefore, a cohort study, in which the investigator identifies exposed and nonexposed groups of patients and follows them to monitor outcome, may provide the best level of evidence, particularly when the information comes from a large database and statistical techniques are used to allow for imbalances due to confounding variables.

G. age and obesity) do not play a role in CVST limit our understanding of the disease. Further multicentered, case-controlled studies are crucial for determining the etiology of, and, therefore, methods for the prevention of, CVST. References 1 2 3 4 5 6 7 8 Levine M, Walter S, Lee H, Haines T, Holbrook A, Moyer V: Users’ guides to the medical literature. IV. How to use an article about harm. Evidence-Based Medicine Working Group. JAMA 1994;271:1615–1619. Baillar JC III: The promise and problems of meta-analysis.

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